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The Science of Obsession: What the Brain Does in Limerence

  • Writer: Orly Miller
    Orly Miller
  • Oct 16, 2025
  • 2 min read

Limerence is not just a feeling. It is a biochemical dance inside the brain that pulls us into longing, hope, and turmoil. When we think about someone with obsessive intensity, it is not only the heart responding but entire neural circuits lighting up. In neuroscience research on romantic love and passion, we see parts of the brain called the ventral tegmental area, nucleus accumbens, and caudate becoming active when a person is in love. These reward centres are governed by dopamine, the chemical of wanting, and by oxytocin, which helps bond us to others.


What often makes limerence so compelling is uncertainty. When love or connection feels uncertain and the other person’s feelings are ambiguous or unpredictable, the brain’s reward system becomes more strongly activated. Uncertainty turns small cues into big signals. A text received, a glance shared, or a sign of interest becomes a dopamine hit. But when interest seems withdrawn, the brain struggles to recalibrate, triggering anxiety, obsessing, and ruminating.


Attachment patterns also play a role. People with anxious attachment styles may have nervous systems more easily triggered by rejection or by lack of reciprocation. The same brain regions respond more strongly to cues of reward or social connection, and in the absence of consistency, they stay on edge. Limerence becomes a loop: reward, hope, disappointment, and craving more reward.


Over time, the constant emotional ups and downs can dysregulate the nervous system. Sleep may suffer, concentration falters, and emotional regulation becomes harder. The brain is plastic and develops in response to repeated experience. When obsession becomes a habit, the neural pathways that support longing become stronger, making it harder to shift out of limerence without intentional awareness or intervention.


Part of healing involves rewiring. It means slowing down the dopamine spikes, creating more reliability in relationships, and building practices that soothe uncertainty. Therapy, mindfulness, body-based regulation, and turning toward secure attachment all help. Awareness of what is happening in your brain can be powerful not just for self-understanding but for change.


If you have felt wrapped up in limerence, it may help to remember that your brain is doing what brains naturally do. It is reacting to reward, craving connection, and reeling from uncertainty. This does not make what you are going through invalid. It just means that there are pathways for healing. My upcoming book Limerence: The Psychopathology of Loving Too Much explores these dynamics in more depth and offers tools to help you find clarity in longing.


If you find yourself caught in patterns of limerence, know that you are not alone. With the right support, it is possible to move beyond obsession and build healthier relationships. I offer individual and couples therapy online and in Mullumbimby. Book a session here. For a deeper exploration, my book Limerence: The Psychopathology of Loving Too Much will be released on December 23 and may offer guidance on your healing journey.


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